Hashish sativa, also called marijuana or hemp, produces a non-psychoactive compound cannabidiol (CBD). To analyze the defensive function of CBD, a feeding desire assay was carried out with tobacco hornworm Manduca sexta. The larvae clearly present feeding desire in direction of the Hashish tissue containing low CBD over excessive CBD. Whereas the larva prevented the excessive CBD weight loss plan, we investigated detrimental results of CBD within the bugs’ weight loss plan. Contrasted to the efficiency on low CBD-infused synthetic weight loss plan (AD), larvae reared on the excessive CBD weight loss plan undergo considerably lowered development and elevated mortality. By way of testing completely different carriers, we discovered that the rise of EtOH within the weight loss plan is negatively correlated with insect growth and behaviors. Notably, CBD therapy considerably improved ethanol-intoxicated larval survival charge by 40% and in addition improved weight loss plan looking out exercise, leading to elevated weight loss plan consumption. Electrophysiology outcomes revealed that the CBD-treated ganglia had delayed however a lot bigger response with electrical stimuli compared to the larvae reared on AD solely and EtOH-added weight loss plan. Our outcomes present CBDs’ defensive function in opposition to pest bugs, which suggests its doable use as an insecticide. We additionally present proof that CBD alleviates alcohol-induced stress; consequently, bettering the efficiency and viability of M. sexta larvae.