Within the early a part of the 20th century, flavonoids had their first massive second. In 1936, the Hungarian doctor István Rusznyák and biochemist Albert Szent-Györgyi revealed a examine within the journal Nature on the well being advantages of those non-intoxicating natural chemical substances. Szent-Györgyi, who had additionally carried out necessary work on vitamin C and fumaric acid, received the Nobel Prize for Drugs the next yr.

Early analysis confirmed thrilling potentialities for flavonoids, highlighting the anti-inflammatory, antioxidant, anti-viral, and anti-cancer results that proceed to intrigue fashionable researchers. Flavonoids even earned the nickname “Vitamin P,” though the expression has since gone out of fashion. 

But very similar to terpenes, one other lesser-known class of chemical substances discovered within the cannabis plant, flavonoids have additionally struggled for official recognition as medicines — neither the U.S. Meals and Drug Administration (FDA) nor the European Meals Security Authority (EFSA) has accredited any well being declare for flavonoids or accredited any as pharmaceutical medication.

However with cannabis analysis seemingly on the verge of a renaissance, the plant’s once-obscure compounds are benefitting from the highlight. Which might imply massive issues for these intriguing secondary metabolites additionally discovered within the plant, and their thrilling — and largely unharnessed — potential.

Vitexin: A Flavonoid on the Coronary heart of Pure Medicines

As with terpenes (like limonene) and even some cannabinoids (like beta-caryophyllene), flavonoids usually are not distinctive to cannabis — and vitexin is not any exception. The chemical compound can be discovered within the ardour flower, chaste timber, black bamboo leaves, pearl millet, and hawthorn. Many of those vegetation are recognized for his or her numerous anti-inflammatory and disease-avoidant powers, results wherein vitexin is believed to play a distinguished position.

Hawthorn, whose lively elements are primarily considered the flavonoids vitexin and rutin, has lengthy been valued in Europe as a cardiac tonic. In a 2018 evaluation of previous research revealed within the journal Integrative Drugs, hawthorn was evaluated as a preventative towards coronary heart failure. Although the outcomes of the evaluation have been largely promising, it additionally included a examine whose “puzzling and fairly regarding” outcomes indicated an increase in coronary heart failure charges — though this can be an anomaly, as hawthorn is usually thought-about fairly secure and facet effect-free. 

There have been additionally quite a few circulatory advantages ascribed to hawthorn in previous animal and human research, resembling elevated coronary artery blood stream, enhanced pumping effectivity of the center, a lengthening of the refractory interval, and barely lowered blood strain.

An excellent quantity of analysis has addressed using one other vitexin-heavy plant, ardour flower. Native to the Americas and Asia, psychoactive species of the plant household have lengthy been utilized by Native People for his or her anxiolytic and sedative properties. Germany’s Fee E — the authority for conventional, folks and natural medicines — has accredited ardour flower within the therapy of nervousness and insomnia.

One other plant treatment, the tetradium daniellii which grows wild within the forests of China and Korea, additionally options vitexin. Lengthy utilized in Chinese language and Korean conventional medication for complications, the therapeutic of gastric ulcers and aid from dermatitis, the plant has not attracted a lot consideration from the Western pure medication neighborhood. It will possible change sooner or later, as it’s also implicated within the therapy of Alzheimer’s illness.

There was some scientific analysis on vitexin’s neuroprotectivity, like a 2018 collaborative evaluation within the journal BioMed Analysis Worldwide. Led by researchers in Brazil and India, the examine pointed to vitexin as a compound of curiosity within the therapy of neurodegenerative ailments. The place typical therapy regimens focus primarily on relieving signs, vitexin appears to counteract the processes that induce neurodegeneration, resembling redox imbalance, neuroinflammation, irregular protein aggregation, discount of cognitive talents, and motor impairment.

Extra analysis out of Brazil addressed vitexin’s particular aptitude in stopping the cell toxicity that comes with Alzheimer’s illness. In a 2015 examine revealed within the journal Meals and Chemical Toxicology, scientists discovered that the flavonoid might defend the mind’s PC12 cells from assault by Aβ peptides, that are one of many chief causes of the neurodegeneration that accompanies Alzheimer’s.